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But with moderate doses and limited cycle lengths, Cardarine presents very little risk of side effects and experienced steroids users will simply find it to be a much gentler compound to use. With an extremely short cycle length, Cardarine can generally be considered as safe and is often recommended on the use of anabolic steroids due to its perceived low cost, ease of use, and generally pleasant experience. In humans, the oral administration of a Cardarine-containing supplement has been shown to be safe, with studies suggesting no obvious adverse reactions in otherwise healthy people. 3.2. Erectile dysfunction Although a single oral dose of Cardarine, at 3.4mg is not associated with a significant increase in erectile efficacy, when used in combination with an effective testosterone inhibitor on an individual's regimen an increase in erection may occur with a mean increase of 4.8%, with improvements noted up to 30 hours after the ingestion of Cardarine. Cardarine has been tested at high doses (20mg/kg) in a study comparing 20mg/kg versus 30mg/kg with the latter being the effective dose in the study. In the study in humans, an increase in penile erection with 40-60mg/kg Cardarine was not seen with any other dosing regimen. 4 Cardiovascular health Cardarine has been theorized to influence blood pressure. Cardarine has been documented to increase the systolic blood pressure and diastolic at least in animals and can be reduced with diuretics. The higher the mean arterial blood pressure, the greater the effect on the heart rate. Cardarine has also been seen with increasing oral dosages with increases in blood pressure as high with the highest dose and the lowest being the lowest in animal studies. The relationship of dosing appears to be influenced by the animal species with higher blood pressure being preferred and the lower being the least. Cardarine appeared to increase systolic blood pressure in an animal model and there appear to be benefits with diuretic medication associated with increased nitric oxide (NO) levels (but not as high as the observed beneficial effect of diuretics which is not associated with cardarine). The mechanisms of Cardarine's effect are currently unknown, but it may reduce heart rate at least, which could hypothetically influence blood pressure. 5 Interactions with Hormones 5.1. Testosterone Cardarine, when ingested alongside the recommended dosages of testosterone replacement therapy, appears to decrease the amount taken orally during a standard dose cycle of the drug Related Article: